As the building blocks of biological membranes, lipids have a very complex set of behaviors that, when defective, can be a major distributor of diseases, including cancer. As the only book to date devoted entirely to lipids in membranes, "Transmembrane Dynamics of Lipids" enlists leading research groups to present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes. With an impressive amount of data, this book explores exciting new discoveries that show promising potential for future study.
List of Contributors
Part 1. Assessment Transmembrane Movement and Asymmetry of Lipids
1. Methods for the determination of lipids transmembrane distribution and movement in biological membranes (Andreas Herrmann and Philippe F. Devanx)
2. Detection and measurement of unlabelled lipid transmembrane movement (Ivan Lopez-Montero, Marisela Velez and Philippe F. Devaux)
Part 2. Lipid Assmetry in Cell Membranes
3. New insights in membrane lipid asymmetry in animal and plant cells (Alain Zachowski)
4. Sphingolipid asymmetry and transmembrane translocation in mammalian cells (Gerrit can Meer, Sylvia Neumann and Per Haberkant)
5. Transbilayer movement and distribution of cholesterol (Peter M#ller, Anna Pia Plazzo, and Andreas Herrmann)
Part 3. Energy Independent Protein-Mediated Transmembrane Movement of Lipids
6. Phospholipid flip-flop in biogenic membranes (Andreas Herrmann and Anant K. Menon)
7. Phospholipid Scramblase - When phospholipid asymmetry goes away (Edouard M. Bevers and Patrick L. Williamson)
Part 4. Energy dependent Lipid Transport across Membranes
8. Flip or flop: mechanism and (patho)physiology of P4-ATPase-catalysed lipid transport (Patricia M. Verhulst, Thomas G. Pomorski and Joost C. M. Holthuis)
9. Coupling Drs2p to phospholipid translocation, membrane asymmetry and vesicle budding (Xiaoming Zhou, Ke Liu, Paramasivam Natarajan, Baby-Periyanayaki Muthusamy and Todd R. Graham)
10. Substrate specificity of the aminophospholipid flippase (Shelley M. Cook and David L. Daleke)
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Philippe F. Devaux, PhD, is Professor of Physics at the Paris 7 University.He has long-standing expertise in teaching molecular and cellular biophysics and physics applied to biology and medicine. He is the author of almost two hundred scientific papers and three books, and is an Editor of the European Biophysics Journal. Andreas Herrmann, PhD, is Professor of Molecular Biophysics at Humboldt-University of Berlin. He teaches courses on the subjects of molecular; cell; and membrane biophysics, optical spectroscopy, and fluorescence microscopy. He is the author of more than two hundred scientific papers focusing on lipid dynamics in biological membranes and molecular mechanisms of virus infection.