Two historians and philosophers of science offer an essential primer on the meaning and limits of regeneration.
In punishment for his stealing fire, the Greek gods chained Prometheus to a rock, where every day an eagle plucked out his liver, and every night the liver regenerated. While Prometheus may be a figure of myth, scholars today ask whether ancient Greeks knew that the human liver does, in fact, have a special capacity to regenerate. Some organs and tissues can regenerate, while others cannot, and some organisms can regenerate more fully and more easily than others. Cut an earthworm in half, and two wiggly worms may confront you. Cut off the head of a hydra, and it may grow a new head. Cut off a human arm, and the human will be missing an arm. Why the differences? What are the limits of regeneration, and how, when, and why does it occur?
In What Is Regeneration?, historians and philosophers of science Jane Maienschein and Kate MacCord explore biological regeneration, delving into a topic of increasing interest in light of regenerative medicine, new tools in developmental and neurobiology, and the urgent need to understand and repair damage to ecosystems brought on by climate change. Looking across scales, from germ, nerve, and stem cells to individual organisms and complex systems, this short and accessible introduction poses a range of deep and provocative questions: What conditions allow some damaged microbiomes to regenerate where others do not? Why are forests following a fire said to regenerate sometimes but not always? And in the face of climate change in the era called the Anthropocene, can the planet regenerate to become healthy again, or will the global ecosystem collapse?
Jane Maienschein is University Professor, Regents Professor, and President’s Professor at Arizona State University, where she also directs the Center for Biology and Society. She also serves as fellow and director of the History and Philosophy of Science Project at the Marine Biological Laboratory in Woods Hole, Massachusetts. She is co-editor of Why Study Biology by the Sea?, also published by the University of Chicago Press.
Kate MacCord is an instructor in the School of Life Sciences at Arizona State University and the program administrator of the McDonnell Initiative at the Marine Biological Laboratory, where she also serves as the McDonnell Fellow.
"How [do] bodies, communities and systems regenerate[?] This is a pressing issue in regenerative medicine, in developmental biology and in neuroscience. In What Is Regeneration?, philosophers of science Jane Maienschein and Kate MacCord point out that this rapidly growing field of study also promises to transform our ability to understand and repair the damage to ecosystems brought on by climate change."
– New Scientist
"A truly thought-provoking book, meant not only for students and scientists, but also politicians and laypersons."
– Eric Röttinger, Institute for Research on Cancer and Aging, Université Côte d'Azur, France
"The book shows exceptional strengths and represents a unique approach that is not only beneficial for a wide audience, but also is needed to face current challenges to humanity and global ecological developments. An essential contribution."
– Hanna Lucia Worliczek, University of Vienna, Austria