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This new edition serves as a guide to the common statistical problems encountered in using animal models in toxicology research and the methodologies that are available to solve them. Enriched by the inclusion of discussions of why a particular procedure or interpretation is suggested, this volume offers innovative, practical advice. With clear enumeration of the assumptions that are necessary for a procedure to be valid, and by worked-through examples and problems drawn from the actual practice of toxicology, this edition is essential for both practicing and student toxicologists.