About this book
Vital life processes occur within the active sites of large biological macromolecules such as proteins, nucleic acids, and lipids. These nanodimensional structures greatly accelerate biological reactions. The chirality of the reactants also has a strong influence on the process, but its importance in such biological reactions has only recently begun to be understood.
This book explores the influence of chirality on reaction mechanisms in such biological nanospaces. The text addresses the influence of the chirality of amino acid and sugar in the active sites of transferase, oxidoreductases, hydrolases, lysases, isomerase, ligases, and other systems. It also covers ribosomal architecture.
Contents
Introduction
Chirality and chiral discrimination
Enzymes, active site, and vital biological reactions
Chirality and reactions in active sites
References
Chiral discrimination in the active site of oxidoreductase
Cytochrome P450: discrimination in drug (warfarin) interaction
Enantioselectivity of hydride transfer of NADPH by alcohol oxidoreductase and conversion of epoxide to #-keto acid by 2-[(R)-2-hydroxypropylthio]-ethanesulfonate dehydrogenase
Lipooxygenase and cyclooxygenase: generation of chiral peroxide from achiral polyunsaturated fatty acid
Nitric oxide synthase: effects of substrate and cofactors on chiral discrimination for binding the enantiomeric ligands
Enoyl reductase: chirality dependent branching of a growing polyketide chain
References
Transferases and chiral discrimination
Peptidyl transferase center within ribosome: peptide bond formation and chiral discrimination
Chiral discrimination by telomerase
Chiral discrimination by HIV-1 reverse transcriptase
Chiral discrimination and nuclear DNA polymerases
References
Influence of chirality on the hydrolysis reactions within the active site of hydrolases
Chiral discrimination by epoxide hydrolases
Chiral discrimination by lipases
References
Influence of chirality on the reactions in the active site of lyases
Hydroxynitrile lyases: interaction with chiral substrates
Acceptance of both epimers of uronic acid by chondroitin lyase ABC
References
Chiral discrimination in the active site of ligases
Chiral discrimination by germacrene d synthases
Chiral discrimination by aminoacyl-tRNA synthetases
References
Summary and future
References
Index
Customer Reviews
Biography
Nilashis Nandi was born in Cooch Behar, West Bengal, India (1965). He received his B.Sc. (Hons.) (1983) and M.Sc. (1985) degrees from North Bengal University and Ph.D. (1992) from Visva Bharati University. He became a postdoctoral fellow at the Indian Institute of Science, India (1993--1997), a J.S.P.S. postdoctoral fellow at Nagoya University, Japan (1997--1999), and an Alexander von Humboldt postdoctoral fellow at the Max Planck Institute of Colloids and Interfaces, Germany (1999--2000). Dr. Nandi was a faculty member in the chemistry group of Birla Institute of Technology and Science, Pilani, India from 2001--2007 and became a professor in the Department of Chemistry, University of Kalyani in 2008 where he has worked ever since. His research interest is focused on theoretical and computational studies in biophysical chemistry.
