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Academic & Professional Books  Organismal to Molecular Biology  Genetics

Genomics: Oxford Biology Primers

Textbook New
By: Lia Chappell(Author), Sarah J Lindsay(Author), Phil Jones(Author), Julian Parkhill(Author), Jonathon Roberts(Author), Nancy Holroyd(Author), Michal Szpak(Author), Francesca Gale(Author), Ann Fullick(Editor)
179 pages, colour & b/w photos, colour illustrations
Genomics: Oxford Biology Primers
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  • Genomics: Oxford Biology Primers ISBN: 9780198848387 Paperback May 2020 In stock
    £19.99
    #247597
Price: £19.99
About this book Contents Customer reviews Biography Related titles

About this book

This Oxford Biology Primer introduces students to the field of genomics and its applications. From the early days of the Human Genome Project, sequencing technology has rapidly developed and is now cheaper and more accessible than ever before. The resulting pervasive nature of these technologies make them more likely to be experienced by people as patients, consumers and citizens.

The primer introduces the basic principles of genomics and then uses these to consider human genetics, through examples of some of the rare diseases linked to single genes. The impact of these rare diseases is far-reaching and the knowledge gained through genome sequencing is proving invaluable in their diagnosis.

Genome sequencing is revolutionising the diagnosis and treatment of cancer, and the primer introduces students to some of the key breakthroughs which have taken place in recent years. These include the identification of specific genes indicating cancer risk, and the sequencing of tumours throughout treatment to identify further mutations and modify treatment accordingly.

The primer aims to address a number of the ethical issues which are raised by this rapidly-growing area of biology. Students are challenged to consider some of the decisions they may need to make relating to these technologies in their own lives, and are given opportunities to explore different aspects of these issues in a way which allows discussion to be both informed and meaningful.

The study of infectious disease is also feeling the impact of genomics: the primer discusses the concept of pathogen genome sequencing, and illustrates the various ways in which this can be used – for example, enabling us to find different solutions to infections, to track outbreaks of disease to their source, and to identify and possibly ultimately combat antibiotic resistance.

Many of the major diseases which impact the global population are caused by parasites, which come in a wide variety of shapes and sizes. The primer introduces students to the importance of understanding parasite genomes. Parasite genome sequencing makes it possible to develop both new medicines, and new treatments such as gene drive systems to wipe out disease-causing mosquito populations.

For many years, our views of classification and evolution have been based on observational techniques going back to Darwin and Linnaeus. Focusing on human evolution, the primer will open students' eyes to the ways in which genome sequencing is being used to reveal evolutionary links that have never before been recognised, and to elucidate the way humans spread out of Africa across the world.

Students are not always aware of the role technological developments play in enabling the progress of science. The final chapter delves into how genome sequencing technologies have developed, considering both the speed of change in the technology, its implications for usefulness, availability and cost, and the growing issue of big data and how it can be manipulated. The different technologies described in this chapter are referenced throughout Genomics.

Contents

1: Rare diseases: a genomics perspective
2: Cancer genomics
3: Genomes and ethics
4: Pathogen Genomics
5: Parasite Genomics
6: Human evolution
7: Genomics: reading and writing genomes

Customer Reviews

Biography

Professor Julian Parkhill FRS is Head of Infection Genomics at the Wellcome Sanger Institute. Dr Sarah J. Lindsay is Senior Staff Scientist at the Wellcome Sanger Institute. Dr Phil Jones is Senior Group Leader at the Wellcome Sanger Institute. Dr Lia Chappell is a Postdoctoral Fellow in single-cell genomics at the Wellcome Sanger Institute. Mr Jonathan Roberts is Genetic Counsellor in the Society and Ethics Research Group, Connecting Science at the Wellcome Genome Campus. Dr Nancy Holroyd is a Project Manager in parasite genomics at the Wellcome Sanger Institute. Dr Michal Szpak is a Postdoctoral Fellow at the Wellcome Sanger Institute. Francesca Gale is Education Development Lead at the Wellcome Sanger Institute.

Textbook New
By: Lia Chappell(Author), Sarah J Lindsay(Author), Phil Jones(Author), Julian Parkhill(Author), Jonathon Roberts(Author), Nancy Holroyd(Author), Michal Szpak(Author), Francesca Gale(Author), Ann Fullick(Editor)
179 pages, colour & b/w photos, colour illustrations
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