About this book
The Twenty-Eighth Edition has undergone sweeping changes - including a conversion to full-color artwork and the substantial revision and updating of every chapter - all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible.
Contents
1. Biochemistry and Medicine
2. Water & PH
3. Amino Acids and Peptides
4. Proteins: Determination of Primary Structure
5. Proteins: Higher Orders of Structure
6. Proteins: Myoglobin and Hemoglobin
7. Enzymes: Mechanisms of Action
8. Enzymes: Kinetics
9. Enzymes: Regulation of Activities
10. Bioenergetics: The Role of ATP
11. Biologic Oxidation
12. The Respiratory Chain & Oxidative Phosphorylation
13. Carbohydrates of Physiologic Significance
14. lipids of Physiologic Significance
15. Overview of Metabolism
16. The Citric acid Cycle: The Catabolism of Acetyl-CoA
17. Glycolysis and Oxidation of Pyruvate
18. Metabolism of Glycogen
19. Gluconeogenesis and Control of the Blood Glucose
20. The Pentose Phosphate Pathway & other Pathways of Hexose Metabolism
21. Biosynthesis of Fatty Acids
22. Oxidation of Fatty Acids: Ketogenesis
23. Metabolism of Unsaturated Fatty Acids & Eicosanoids
24. Metabolism of Acyglycerols and Sphingolipids
25. Lipid Transport And Storage
26. Cholesterol Synthesis, Transport and Excretion
27. Integration of Metabolism- the Provision of Metabolic Fuels
28. Biosynthesis of Nutritionally Nonessential Amino Acids
29. Catabolism of Proteins & of Amino Acid Nitrogen
30. Catabolism of the Carbon Skeletons of Amino Acids
31. Conversion of Amino Acids
32. Porphyrins & Bile Pigments
33. Nucleotides
34. Metabolism of Purine & Pyrimidine Nucleotides
35. Nucleic Acid Structure and Function
36. DNA Organization, Replication and Repair
37. RNA Synthesis, Processing and Modifications
38. Protein Synthesis and Genetic Code
39. Regulation of Gene Expression
40. Molecular Genetics, Recombinant DNE and Genomic Technology
41. Membranes: Structure and Function
42. The Diversity of Endocrine System
43. Hormone Action and Signal Transduction
44. Nutrition, Digestion and Absorption
45. Vitamins and Minerals
46. Intracellular Traffic and Sorting of Proteins
47. Glycoprotein
48. The Extracellular Matrix
49. Muscle and the Cytoskeleton
50. Plasma Proteins and Immunoglobulins
51. Homeostasis and Thrombosis
52. The Red and White Blood Cells
53. Metabolism of Xenobiotics
54. The Human Genome Project
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Biography
Robert K. Murray, MD, PhD, Professor (Emeritus) of Biochemistry, University of Toronto David A. Bender, PhD, Sub-Dean, University College Medical School, Senior Lecturer in Biochemistry, Department of Structural and Molecular Biology and Division of Medical Education, University College London Kathleen M. Botham, PhD, DSc, Professor of Biochemistry, Royal Veterinary College, University of London Peter J. Kennelly, PhD, Professor and Head, Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia Victor W. Rodwell, PhD, Emeritus Professor of Biochemistry, Purdue University, West Lafayette, Indiana P. Anthony Weil, PhD, Professor of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee Co-Authors: Daryl K. Granner, MD, Emeritus Professor of Molecular Physiology and Biophysics and Medicine, Vanderbilt University, Nashville, Tennessee Peter L. Gross MD, MSc, FRCP(C), Associate Professor, Department of Medicine, McMaster University Frederick W. Keeley, PhD, Associate Director and Senior Scientist, Research Institute, Hospital for Sick Children, Toronto, and Professor, Department of Biochemistry, University of Toronto Peter A. Mayes, PhD, DSc, Emeritus Professor of Veterinary Biochemistry, Royal Veterinary College, University of London Margaret L. Rand, PhD, Associate Senior Scientist, Hospital for Sick Children, Toronto, and Professor, Departments of Laboratory Medicine and Pathobiology and Department of Biochemistry, University of Toronto