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About this book
About this book
Providing a detailed description of the relationship between protein structure, function, and dynamics, this book adopts an energy-oriented approach to discuss structural-biophysical aspects, molecular interactions, and thermodynamic changes that transpire in proteins. It presents the energetics of protein structure, guidelines to clarify protein action based on the structure-function relationship of protein-ligands, and the myriad functions of intrinsically unstructured proteins. The authors also describe current experimental and computational methods for studying structure and dynamics. The text includes various Internet-based resources, such as databases and algorithms, as well as applications to human disease, drug design, chemical warfare, and more.
Introduction THE IMPORTANCE OF PROTEINS IN LIVING ORGANISMS STRUCTURAL COMPLEXITY AND ITS EFFECT ON PROTEIN FUNCTION NON-COVALENT INTERACTIONS BETWEEN ATOMS IN BIOMOLECULES Protein Structure INTRODUCTION PRIMARY STRUCTURE SECONDARY STRUCTURE TERTIARY STRUCTURE QUATERNARY STRUCTURE POST-TRANSLATIONAL MODIFICATIONS Methods of Structure Determination and Prediction INTRODUCTION DIFFRACTION/SCATTERING METHODS SPECTROSCOPIC METHODS COMPUTATIONAL METHODS FOR STRUCTURE PREDICTION CONCLUSIONS THE PROTEIN DATA BANK (PDB) Energetics and Protein Stability BASIC PRINCIPLES OF THERMODYNAMICS PROTEIN STABILITY AND THE FORCES INVOLVED PROTEIN DENATURATION AND ADAPTATION TO EXTREME CONDITIONS STABILITY ENHANCEMENT OF INDUSTRIAL ENZYMES USING PROTEIN ENGINEERING Protein Structural Dynamics INTRODUCTION PROTEIN FOLDING FOLDED STATE DYNAMICS METHODS FOR STUDYING PROTEIN DYNAMICS Non-Globular Proteins INTRODUCTION FIBROUS PROTEINS INTRINSICALLY UNSTRUCTURED PROTEINS Membrane Proteins INTRODUCTION STRUCTURE AND ORGANIZATION OF BIOLOGICAL MEMBRANES PRINCIPLES OF MEMBRANE PROTEIN STRUCTURE PROTEIN--MEMBRANE INTERACTIONS STRUCTURE--FUNCTION RELATIONSHIP IN MEMBRANE PROTEINS AND PEPTIDES Protein--Ligand Interactions INTRODUCTION THEORIES ON PROTEIN--LIGAND BINDING PROTEIN--LIGAND BINDING ENERGETICS THE LIGAND-BINDING SITE PROTEIN--PROTEIN INTERACTIONS PROTEIN--LIGAND INTERACTIONS IN DRUG ACTION AND DESIGN Index A Summary and References appear at the end of each chapter.
Amit Kessel is co-founder of Es-is Technologies Ltd., which designs biocatalysts for the pharmaceutical industry. He also teaches protein biochemistry and biophysics at the Tel Aviv-Yaffo Academic College. During his postdoctoral research at Columbia University, Dr. Kessel focused on various physicochemical aspects of protein--protein interactions at the molecular level. Nir Ben-Tal is a professor in the Department of Biochemistry and Molecular Biology at Tel-Aviv University. His research in computational biology has involved predicting the three-dimensional structures of transmembrane proteins and developing the ConSurf web server for the detection of functional regions by mapping evolutionary data on protein structures.
644 pages, 375 black & white illustrations, 8 black & white tables
The book by Kessel and Ben-Tal offers a unique combination of structure, thermodynamics and biology. I was impressed both by the breadth of the topics covered and by the depth in which they are treated. General principles are made intuitively clear based on well-chosen examples, many of them having relevance to disease. The book could fit well as a textbook in structural biology and molecular biophysics courses. --Barry Honig, Columbia University, New York, New York, USA ! the book provides general guidelines for understanding protein structure and demonstrates how we can use the structure to phrase testable hypotheses about biological function. ! The repeated use of the same example makes it easier for the reader to grasp the general principles. The book gives a coherent picture of each topic ! [and] includes ample references, making it possible for the interested reader to dig deeply into various topics. The book also covers structural aspects of intrinsically unstructured proteins and how this property facilitates their biological function. ! The book provides background in cell biology, basic chemistry and thermodynamics, making it useful for newcomers to the protein structure field who want to catch up quickly. ! it [is also] easy for experts to dive into the more specialized aspects quickly. ! The book provides references to user-friendly web tools in the field. The publisher's website provides exercises on both theory and practice. Sample solutions and PowerPoint presentations are available for qualified teachers. These make the book attractive as the main textbook in an undergraduate course on protein structure. Perhaps also for parts of freshman biochemistry. ! useful as supplement for many undergraduate and graduate courses. --Burkhard Rost, Technische Universitat Munchen, Germany