644 pages, 375 black & white illustrations, 8 black & white tables
Providing a detailed description of the relationship between protein structure, function, and dynamics, this book adopts an energy-oriented approach to discuss structural-biophysical aspects, molecular interactions, and thermodynamic changes that transpire in proteins. It presents the energetics of protein structure, guidelines to clarify protein action based on the structure-function relationship of protein-ligands, and the myriad functions of intrinsically unstructured proteins. The authors also describe current experimental and computational methods for studying structure and dynamics. The text includes various Internet-based resources, such as databases and algorithms, as well as applications to human disease, drug design, chemical warfare, and more.
The book by Kessel and Ben-Tal offers a unique combination of structure, thermodynamics and biology. I was impressed both by the breadth of the topics covered and by the depth in which they are treated. General principles are made intuitively clear based on well-chosen examples, many of them having relevance to disease. The book could fit well as a textbook in structural biology and molecular biophysics courses. --Barry Honig, Columbia University, New York, New York, USA ! the book provides general guidelines for understanding protein structure and demonstrates how we can use the structure to phrase testable hypotheses about biological function. ! The repeated use of the same example makes it easier for the reader to grasp the general principles. The book gives a coherent picture of each topic ! [and] includes ample references, making it possible for the interested reader to dig deeply into various topics. The book also covers structural aspects of intrinsically unstructured proteins and how this property facilitates their biological function. ! The book provides background in cell biology, basic chemistry and thermodynamics, making it useful for newcomers to the protein structure field who want to catch up quickly. ! it [is also] easy for experts to dive into the more specialized aspects quickly. ! The book provides references to user-friendly web tools in the field. The publisher's website provides exercises on both theory and practice. Sample solutions and PowerPoint presentations are available for qualified teachers. These make the book attractive as the main textbook in an undergraduate course on protein structure. Perhaps also for parts of freshman biochemistry. ! useful as supplement for many undergraduate and graduate courses. --Burkhard Rost, Technische Universitat Munchen, Germany
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