Parasitic Nematodes Molecular Biology, Biochemistry and Immunology

About this book

Covering a wide range of rapidly-developing fields of research into parasitic nematodes, this comprehensive volume discusses the genetics, biochemistry and immunology of nematode parasites of humans as well as domestic animals and plants.

This fully-updated edition also covers new advances including horizontal gene transfer, immune expulsion mechanisms, genetics of susceptibility in humans, nematode protein structures, role of bacterial symbionts, intrinsic immune response, host immune system modulation, modulation of allergic and autoimmune diseases and the use of parasitic nematodes or their products as therapeutics.

Contents

Part 1. Evolution of parasitism and life history adaptations
1. The genome of Pristionchus and the evolution of parasitism
2. Life history placticity and responses to host defense
3. Horizontal gene transmission in plant parasites
4. Innate Immunity in Caenorhabditis elegans


Part 2. Modulation of the host immune response
5. Nematodes and T regulatory cells
6. The alternatively activated macrophage
7. Modulation of autoimmune and allergic responses by defined nematode molecules
8. Tracking the host response in nematode immunity
9. Nematodes and regulation of the inflammatory response


Part 3. Genetics of susceptibility and resistance
10. Susceptibility of humans to Ascaris
11. Genetics of resistance to hookworm
12. Population genetics and anthelmintic resistance to nematodes of domestic animals
13. Asthma, allergy and parasitic worm infections
14. Genetics of susceptibility - wild animals


Part 4. Protection systems - Immune effectors, therapeutics, vaccines
15. Wolbachia as a therapeutic target
16. Intestinal immune rejection mechanisms, specific and non-specific
17. Nematodes and human therapeutic trials
18. Vaccination against hookworms
19. Vaccination against filarial nematodes
20. Vaccination against nematodes of domestic animals
21. Immune regulation and multiple species infections
22. Effect of nematode infection on the immune response to other pathogens
23. Genetics of drug resistance in nematodes


Part 5. Specialised and novel structures
24. Nervous system and neural communication molecules
25. Host cell and tissue modification
26. Cuticle synthesis and modification
27. Proteinases, from free-living to parasite
28. Nematode polyprotein structure

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