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While there are many textbooks available that provide all the information bench scientists, researchers, and students need to carry out "wet" laboratory experiments, very few sufficiently address computer-based functional annotation. Furthermore, most books on bioinformatics and computational biology focus on the genomic DNA aspects and all but overlook the vast and important area of protein bioinformatics. This book fills those gaps. It provides a comprehensive introduction to the computer-based analysis of proteins at the sequence, structure, and functional levels.