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Systems biology is the study of organisms as interacting networks of genes, proteins and reactions. Practical Systems Biology provides a detailed overview of the different approaches used in this relatively new discipline, integrating bioinformatics, genomics, proteomics and metabolomics. Various areas of research are also discussed, including the use of computational models of biological processes, and post-genomic research.
Each chapter is written by an experienced researcher and gives an excellent account of various issues of systems biology that is suitable for postgraduate and postdoctoral researchers who are interested in this expanding area of science.
Chapter 1: Bioinformatic Approaches to Biological Systems
Chapter 2: Cell sampling and global nucleic acid amplification
Chapter 3: Methods of Proteome Analysis: Challenges and Opportunities
Chapter 4: Vertical Systems Biology: From DNA to flux and back
Chapter 5: Using mathematical models to probe dynamic expression data
Chapter 6: Gene regulatory network models: a dynamic and integrative approach to development
Chapter 7: Spatio-temporal Dynamics of Protein Modification Cascades
Chapter 8: Intracellular Signaling During Bacterial Chemotaxis
Chapter 9: Modeling the mammalian heart
Chapter 10: Modeling root growth and development