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The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research

Handbook / Manual

Edited By: Bryan Robert Howard, Timo Nevalainen and Gemma Perretta

440 pages, 43 black & white illustrations, 33 black & white tables

CRC Press

Hardback | Oct 2010 | #186266 | ISBN-13: 9781439824924
Availability: Usually dispatched within 6 days Details
NHBS Price: £57.99 $76/€65 approx

About this book

COST (European Cooperation in the field of Scientific and Technical Research) is an intergovernmental initiative in science and research intended to promote the coordination of nationally funded research at a European level. In laboratory animal science, four working groups were established to discuss the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the activities of these working groups, this book provides the European best practices for individuals and institutions working with laboratory animals. The text also provides a guide for the ethical evaluation of experiments and procedures involving animals.


Introduction Design and management of facilities Education and training Housing and care Environmental needs Animal model selection and preconditioning Procedures including administration of substances/dosing, handling, sampling Anaesthesia and analgesia Euthanasia Remote monitoring Humane endpoints and recognition of pain and distress Experimental design Production of transgenic lines Transgenic line management, including archiving Guide for ethical evaluation of procedures for experiments involving animals Communications Vision for the future

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Bryan Robert Howard is the former Director of Animal Welfare at the University of Sheffield. Timo Nevalainen is a Professor of the National Laboratory Animal Center at the University of Kuopio. Gemma Perretta is the Head of the Division of Special Zoology and Animal Models for the Institute of Neurobiology and Molecular Medicine of the Italian National Research Council in Rome.

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