The Role of Nucleotides in the Regulation of Bone Formation and Resorption brings together, for the first time, many of the established experts in the field to provide a balanced overview of a field with considerable interest for both drug development and academic research. The Role of Nucleotides in the Regulation of Bone Formation and Resorption covers all aspects of purinergic signalling in the key skeletal cell types. Emphasis is placed on the roles of nucleotides as mediators of cell interactions in health and disease, including the key areas of inflammation and immune cell function. The text summarizes what is known to date of the actions of nucleotides on skeletal cells and of the likely receptor subtypes involved.
- Purinergic Signaling in Osteoblasts, N. R. Jørgensen and T. H. Steinberg
- P2 Nucleotide Receptor Signaling in Osteoclasts, J. Korcok, S. M. Sims, and S. J. Dixon
- The Role of Purinergic Signaling in the Interactions Between Skeletal Cells, K. A Buckley, A. Gartland, and J. A Gallagher
- Role of Purine and Pyrimidine Nucleotides and Nucleosides in Regulation of Cartilage Metabolism and Chondrocyte Function, H. P. Benton and J. M. Stokes
- ATP Release Mechanisms, G. R. Dubyak
- Purinergic Signaling in Inflammation and Immunomodulation, F. Di Virgilio and I. Lemaire
- Future Directions, G. Burnstock and T. Arnett