About this book
Completely revised and updated to reflect advances in the field, this new edition focuses on lipids and the lipid bilayer, as well as on membrane protein structure and function, and includes a chapter on transport. It provides an integrated view of membranes as functioning units and incorporates recent advances in membrane protein structure, membrane rafts and membrane fusion. The roles of cholesterol in the biology of cells, the structures of G-protein coupled receptors, membrane lipids as modulators of membrane-bound enzymes, and viral fusion mechanisms are presented and analyzed in depth.
MEMBRANE LIPID STRUCTURE AND FUNCTION.
The Mesomorphic Phase Behavior of Lipid Bilayers.
Lipid Bilayer Interdigitation.
The Dynamics of Membrane Lipids.
Non-Lamellar Lipid Phases.
The Forces Between Interacting Bilayer Membranes and the Hydration of Phospholipid Assemblies.
The Roles of Cholesterol in the Biology of Cells.
Lipid Membrane Fusion.
MEMBRANE PROTEIN STRUCTURE AND FUNCTION.
Passive and Facilitated Transport.
Membrane Protein Dynamics: Rotational Dynamics.
Translational Diffusion of Membrane Proteins.
Inorganic Anion Transporter AE1.
The Structures of G-Protein Coupled Receptors.
Role of Membrane Lipids in Modulating the Activity of Membrane-Bound Enzymes.
Viral Fusion Mechanisms.
Philip L. Yeagle is dean of the Faculty of Arts and Sciences and chief academic research officer at Rutgers University, Newark, New Jersey. He obtained his PhD at Duke University in 1974. As a postdoctoral fellow at the University of Virginia, he started his studies of membrane structure and dynamics, supported by an NIH postdoctoral fellowship. There he was one of the first investigators to discover and exploit the opportunities for 31P NMR studies of model and biological membranes. He began his faculty career in the School of Medicine, University at Buffalo, supported by an NIH RCDA, during which time he was able to define the molecular basis of an essential role of cholesterol in mammalian cell membranes. In 1985, he was a visiting scientist at the CSIRO, New South Wales, Australia, and in 1988 he developed the first in a series of FASEB Summer Research Conferences on membrane structure. In 1993, and again in 2003, he was a visiting professor in the Department of Biochemistry, University of Oxford. He moved in 1997 to the Department of Molecular and Cell Biology at the University of Connecticut as head of department and pursued studies of membrane protein structure. He was elected member of the Council of the Biophysical Society and chair of the Membrane Structure and Assembly subgroup that he helped form. He was executive editor of Biochemica et Biophysica Acta Biomembranes for a decade and a member of the editorial board of the Journal of Biological Chemistry. He has published over 150 papers and reviews and is the author or editor of seven books.