Members of the transforming growth factor ß (TGFß) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell proliferation and embryonic development. The TGF-β Family provides a comprehensive view of the different members of the TGFß family and their receptors, as well as their roles in normal physiology and development and pathological conditions such as cancer.
1. The discovery and early days of TGF-β: a historical perspective.
Hal Moses, Anita Roberts (deceased), Rik Derynck
2. TGF-β and the TGF-β family, context-dependent roles in cell and tissue physiology.
Kohei Miyazono, Rik Derynck
3. Activins and inhibins.
4. Bone morphogenetic proteins.
Takenobu Katagiri, Tetsu Watabe
5. Regulation of the bioavailability of TGF-β and TGF-β-related proteins.
6. Agonists and antagonists of TGF-β family ligands.
7. TGF-β family receptors.
Calle Heldinand Aris Moustakas
8. TGF-β signaling from receptors to Smads.
Akiko Hata, Ye-Guang Chen
9. Transcriptional control by Smads.
10. Post-translational control of Smads.
11. Regulation of TGF-β family signaling by inhibitory Smads.
Keiji Miyazawa, Kohei Miyazono
12. Structural basis of ligand-receptor interactions.
Andrew Hinck, Thomas Müller, Tim Springer
13. Structural basis of intracellular signaling process: receptors and Smads.
14. Non-Smad TGF-β family signaling.
15. Signaling crosstalk in TGF-β signaling.
16. TGF-β family signaling in the control of cell proliferation and survival.
17. TGF-β family signaling in Drosophila.
18. TGF-β family signaling in C. elegans.
Cathy Savage-Dunn, Rick Padgett
19. TGF-β family signaling in early vertebrate development.
20. TGF-β family signaling in embryonic and somatic stem cell renewal and differentiation.
Jeff Wrana, Alan Mullen
21. TGF-β family signaling in epithelial differentiation and epithelial-mesenchymal transition.
22. TGF-β family signaling in mesenchymal differentiation.
Brendan Lee, Yuji Mishina
23. TGF-β family signaling in endothelial cell differentiation, vasculogenesis and angiogenesis.
Peter ten Dijke
24. TGF-β family signaling in the control of hematopoiesis.
Stefan Karlsson, Ulrika Blank
25. TGF-β family signaling in lymphocyte and immune cell differentiation and function.
Shomyseh Sanjabi and Ming Li
26. TGF-β family signaling in neural and neuronal differentiation, development and function.
27. Control of the reproductive system by TGF-β family signaling.
Stephanie Pangas, Martin Matzuk
28. TGF-β family signaling in connective tissue and skeletal diseases.
Eileen Shore, Hal Dietz
29. TGF-β family signaling in tumor suppression and cancer progression.
Joan Seoane and Roger Gomis
30. TGF-β signaling and the tumor micro-environment.
31. TGF-β signaling and fibrosis.
32. TGF-β-based therapeutical approaches.
Lalage Wakefield, Rosemary Akhurst
33. Activin/myostatin-based therapeutic approaches.
Se-Jin Lee, HQ Han
34. BMP-based therapeutic approaches.