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The Toxicology and Biochemistry of Insecticides

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The Toxicology and Biochemistry of Insecticides

Continuing as the sole book in more than two decades to address this...

NHBS Price: £50.99 $67/€58 approx

By: Simon J Yu(Author)

276 pages, illustrations, tables

CRC Press

Hardback | Mar 2008 | Edition: 1 | #173927 | ISBN-13: 9781420059755
Out of Print Details

About this book

The first book in two decades to address this multi-faceted field, The Toxicology and Biochemistry of Insecticides provides the most up-to-date information on insecticide classification, formulation, mode of action, resistance, metabolism, environmental fate, and regulatory legislation. The Toxicology and Biochemistry of Insecticides draws on the author's groundbreaking research in insect detoxification. It discusses mechanisms at the molecular level such as specific enzymes that contribute to insecticide resistance, the modification of which can change insecticide susceptibility and influence host plant selections in phytophagous insects.

Beginning with a general introduction, eleven chapters integrate classical toxicology with physiology, biochemistry, and molecular biology to present a comprehensive look at the field. The Toxicology and Biochemistry of Insecticides discusses the demand and formulation of pesticides and describes each type from dusts and powders to baits and aerosols. It classifies insecticides by target, chemical compound, and mechanism; evaluates toxicity testing procedures; explains pesticide uptake, mode of action, and metabolism; and explores species differences, resistance, and interactions. It also considers pesticides in the environment and federal and state regulatory legislation and enforcement.

A long-awaited, state-of-the-science review on insect toxicology, this indispensable book brings you up-to-date on the many aspects and implications of pesticide use and provides the necessary background and platform from which to conduct future research.

" [...] applicable to a diversity of students from entomology, pest management and related agricultural disciplines. [...] provides an updated and comprehensive introductory textbook for students of insecticide toxicology that incorporates traditional toxicological concepts, including uptake, mode of action, and principles of xenobiotic metabolism with an up-to-date cataloging of both historically important insecticide classes and novel chemistries and their mode of action. This information provides a solid foundation for developing more complex issues, such as the role of xenobiotic metabolism as it relates to selective toxicity and resistance evolution. [...] presents material in an easy to read outline that is well-organized [...] illustrated with many line drawings and tables providing the reader with ample opportunity to interpret data that enhances understanding of a certain topic. [...] this text is a valuable basic reference for students of insecticide toxicology. [...] I have recommended the text for my own course and have received positive feedback from a diversity of students."

– Blair D. Siegfried, Department of Entomology, University of Nebraska-Lincoln


- The Need for Pesticides and Their Pattern of Use
- The Need for Pesticides
- Pattern of Use
- Pesticide Economics
- The Formulation of Pesticides
- Types of Formulation
- The NonPesticidal Ingredients of Formulations
- Pesticide Application Equipment
- Pesticide Laws and Regulations
- The Federal Insecticide, Fungicide, and Rodenticide Act
- The Federal Food, Drug, and Cosmetic Act
- The Food Quality Protection Act
- State Laws
- Enforcement
- The Classification of Insecticides
- Classification of Insecticides
- Evaluation of Toxicity
- Testing Procedures
- Tests with Insects
- Tests with Higher Animals
- Probit Analysis
- Source of Variability in Dose–Response Tests
- The Use of Log Dosage-Probit (LDP) Lines
- Appendix 5.1: An example of probit analysis using the SAS system
- The Uptake of Insecticides
- Penetration of Insecticides Through the Insect Cuticle
- Entry via the Mouth
- Uptake via the Spiracles
- The Mode of Action of Insecticides
- Insecticides Affecting Voltage-Gated Sodium Channels
- Insecticides Affecting Calcium Channels
- Insecticides Inhibiting Acetylcholinesterase
- Insecticides Interfering with GABA-gated Chloride Channels
- Insecticides that Bind to Nicotinic Acetylcholine Receptor
- Insecticides Affecting Octopamine Receptors
- Insecticides Interfering with Respiration
- Insecticides Acting as Alimentary Toxins
- Insecticides Affecting Chitin Biosynthesis or Cuticle Sclerotization
- Insecticides Acting as Juvenile Hormone Mimics
- Insecticides Acting as Ecdysone Agonists, or Blocking Molting Hormone Activity
- Insecticides Abrading or Disrupting Insect Cuticle
- The Mode of Action of Acaricides
- Principles of Pesticide Metabolism
- Phase I Reactions
- Phase II Reactions
- Metabolic Pathways of Selected Insecticides
- Species Differences and Other Phenomena Associated with the Metabolism of Xenobiotics
- Species Differences in Detoxification Enzyme Activity
- Effect of Age and Sex on Enzyme Activity
- The Specificity of Detoxification Enzymes
- Selective Toxicity
- Synergism and Antagonism
- Enzyme Induction
- Insecticide Resistance
- Insecticide Resistance
- The Genetics of Resistance
- Mechanisms of Resistance
- Interaction Phenomena
- Rate of Development of Resistance
- Management of Resistance
- Pesticides in the Environment
- Persistence of Pesticides in Soil
- Photodegradation of Pesticides
- Pesticides and the Food Chain
- Sublethal Effects of Pesticides on Wildlife

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