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A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.
New Strategies in Drug Discovery; Eliot H. Ohlstein, Anthony G. Johnson, John D. Elliot, and Anne M. Romanic; Basic Microarray Analysis: Strategies for Successful Experiments; Scott A. Ness; From Microarray to Biologic Networks: Analysis of Gene Expression Profiles; Xiwei Wu and T. Gregory Dewey; Microarray Analysis in Drug Discovery and Clinical Applications; Siqun Wang and Qiong Cheng; Ontology-Driven Approaches to Analyzing Data in Functional Genomics; Francisco Azuje, Fatima Al-Shahrour, and Joaquin Dopazo; Gene Evolution and Drug Discovery; James O. McInerney, Caroline S. Finnerty, Jennifer M. Commins, and Gayle K. Philip; Standardization of Microarray and Pharmaocogenomics Data; Cassey S. Husser, Jeffrey R. Buchhalter, O. Scott Raffo, Amnon Shabo, Steven H. Brown, Karne E. Lee, and Peter L. Elkin; Clinical Applications of Bioinformatics, Genomics, and Pharmacogenomics; Omer Iqbal; Protein Interactions Probed with Mass Spectrometry; Suma Kaveti and John R. Engen; Discovering New Drug Targeting Sites on Flexible Multi-Domain Protein Kinases: Combining Segmental Isotopic and Site-Directed Spin Labeling for NMR Dectection of Interfacial Clefts; Thomas K. Harris; NMR-Based Screening Methods for Drug Discovery; Laurel Sillerud and Richard S. Larson; Receptor Binding Sites: Bioinformatic Approaches; Darren R. Flower; In Silico Protein Design: Fitting Sequence onto Structure; Bassil I. Dahiyat; Chemical Database Preparation for Compound Acquisition or Virtual Screening; Cristian G. Bolgna, Marius M. Olah, and Tudor I. Oprea; Bioinformatics Platform Development: From Gene to Lead Compound; Alexis S. Ivanov, Alexander V. Veselovsky, Alexander V. Dubanov, and Vladlen S. Skvortsov.
...succeeds admirably in illuminating the latest interdisciplinary techniques being applied to drug discovery, including target selection and validation, receptor binding site characterization and binding prediction, and use for new lead discovery. - Journal of Medicinal Chemistry