Protein Structure Prediction: A Practical Approach

About this book

The three-dimensional structure of proteins is a key factor in their biological activity. There is an increasing need to be able to predict the structure of a protein once its amino-acid sequence is known; this book presents practical methods of achieving that ambitious aim, using the latest computer modelling algorithms. This work is aimed at postgraduates and postdoctoral researchers in protein science and related fields.

Contents

1. Protein structure prediction - principles and approaches; 2. Protein sequence alignment and database scanning; 3. Identification of protein sequence motifs; 4. Prediction of secondary structure; 5. Prediction of transmembrane protein topology; 6. Comparative modelling of proteins; 7. Antibody combining sites: structure and prediction; 8. Protein folds and their recognition from sequence; 9. The combinatorial approach; 10. Modelling protein conformation by molecular mechanics and dynamics; 11. Docking ligands to proteins; 12. The prediction challenge

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