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Diabetes mellitus is known to be a chronic metabolic disorder caused due to an impaired metabolism of glucose and other energy-providing molecules characterized by a slow progression of vascular and neuropathic complications. The present volume reviews the elucidation of several bioactive extracts from 25 potential medicinal plants (largely used in traditional medicine) and their mechanism of action in treatment of diabetes. These 25 herbs have been proved for its anti-diabetic potential using in vitro and in vivo model systems. Several strategies have been used in the management and treatment of diabetes. These strategies are targeted towards increasing endogenous insulin availability (sulfonylureas) enhancing insulin sensitivity and inhibiting a-glucosidase. Experimental evidences presented in core drug have shown and proven that each of these herbs possess bioactive compounds with anti-diabetic properties.
This volume is a comprehensive compilation covering all aspects of diabetes management, touching on topics from definition and etiology, pathophysiology to adversities and toxicology; from pharmacological management to herbal drug delivery through nanotechnology, and insights into the management of metabolic disorders in pharmacology.
The information is presented in two volumes. Diabetes I provides information on the wide range of basic components that are necessary for the management of diabetes and reviews seven medicinal plants. This volume presents a further eighteen plants, namely cinnamon, Coccinia indica, Eucalyptus globulus, Eugenia jambos, Ficus glomerata, Gymnema sylvestris, Ipomea batotos, Medicago sativa, Momordica charantia, Nelumbo nucifera, Nigella sativa, Pongamia pinnata, Swertia chirayita, Syzygium malaccense, Tinospora cordifolia, Trigonella foenum-graceum, Vinca rosea, and Withania somnifera.
Both these volumes have been presented in a manner that is simple and easy to understand, and a balance between theory and practical inputs has been struck. The contributions originate from around the world, including Canada, Ethiopia India, Saudi Arabia, Malaysia, Mauritius, Nigeria, Pakistan, Romania, Spain, and the USA. The volume is aimed at a wide range of audience of ethnobotanists, phytochemists, pharmacologists, pharmacists, pharmacognosists and other researchers engaged in the search for new drugs from natural resources for diabetes mellitus treatment.