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Diabetes mellitus is known to be a chronic metabolic disorder caused due to an impaired metabolism of glucose and other energy-providing molecules characterized by a slow progression of vascular and neuropathic complications. The present volume reviews the elucidation of several bioactive extracts from 25 potential medicinal plants (largely used in traditional medicine) and their mechanism of action in treatment of diabetes. These 25 herbs have been proved for its anti-diabetic potential using in vitro and in vivo model systems. Several strategies have been used in the management and treatment of diabetes. These strategies are targeted towards increasing endogenous insulin availability (sulfonylureas) enhancing insulin sensitivity and inhibiting α-glucosidase. Experimental evidences presented in core drug have shown and proven that each of these herbs possess bioactive compounds with anti-diabetic properties.
This volume is a comprehensive compilation covering all aspects of diabetes management, touching on topics from definition and etiology, pathophysiology to adversities and toxicology; from pharmacological management to herbal drug delivery through nanotechnology, and insights into the management of metabolic disorders in pharmacology.
The information is presented in two volumes. Diabetes I provide information on the wide range of basic components that are necessary for the management of diabetes. Seven medicinal plants are reviewed, namely Adhatoda vasica, Aegle marmelos, Andrographis paniculata, Allium sativum, Annona squamosa, Azadirachta indica, and Carissa edulis. Details are compiled on the isolation of pure compounds in relation to antidiabetic effects and their potential mode of action. The second part, Recent Progress in Medicinal Plants, Volume 46: Diabetes II, presents a further eighteen plants.
Both these volumes have been presented in a manner that is simple and easy to understand, and a balance between theory and practical inputs has been struck. The contributions originate from around the world, including Canada, Ethiopia India, Saudi Arabia, Malaysia, Mauritius, Nigeria, Pakistan, Romania, Spain, and the USA. The volume is aimed at a wide range of audience of ethnobotanists, phytochemists, pharmacologists, pharmacists, pharmacognosists and other researchers engaged in the search for new drugs from natural resources for diabetes mellitus treatment.