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The field of endocrine disruption or endocrine active compounds (EACs), which is just emerging and still controversial, is comprehensively covered by leading experts in Volume 3, Subvolumes L (Part I) and M (the present volume, Part II). The major classes of endocrine active chemicals are discussed, as well as methods for their detection and their association with health disturbances in humans and wildlife. The etiology of several of the human diseases associated with endocrine disruptors, e.g. breast and prostate cancer, decreased fertility and malformations, is still poorly understood, and the current state of knowledge is presented. Since hormonally active agents appear to have the potential of both adverse and beneficial effects, the evidence of health benefits associated with endocrine active compounds in humans is also presented. Basic chapters on the mode of action of EACs and on the etiology of the associated diseases facilitate the understanding of this complex subject for non-medical readers.
Association of Sex Hormones with Disease in Humans: Estrogen and Human Breast Cancer. Role of Sex Hormones in Prostate Cancer. Beneficial and Adverse Effects of Dietary Estrogens on the Human Endocrine System: Clinical and Epidemiological Data * Mechanism-Based Carcinogenic Risk Assessment of Estrogens and Estrogen-Like Compounds: Effects of Endocrine Active Compounds in Experimental Systems. Alteration in Male Reproductive Development: The Role of Endocrine Disrupting Chemicals. Effects of Perinatal Estrogen Exposure on Fertility and Cancer in Mice * Genotoxic Potential of Natural and Synthetic Active Compounds: Association of Endocrine Active Compounds with Environmental Effects. Emerging Issues Related to Endocrine Disrupting Chemicals and Environmental Andogens and Antiandrogens. Development and Reproductive Abnormalities Associated with Endocrine Disruptors in Wildlife. Endocrine Disruptors in the Aquatic Environment.