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This volume offers the most comprehensive presentation available on metal toxicology. It discusses not only metals but also the toxic endpoints, such as neurotoxicity, renal toxicity, and cancer induction. Chapters are written by experts in their respective fields, focusing on carcinogenesis and human exposures and highlighting the major aspects and issues of toxicity in general.
GENERAL AND CLINICAL ASPECTS, RISK ASSESSMENT, AND GENOTOXICITY OF METALSMonitoring, Environmental, and Health Risk Assessments (Anna M. Fan)An Introduction to Monitoring and Environmental and Human Risk Assessment of Metals (Anna M. Fan)Monitoring and Assessment of Metal Contaminants in the Air (Josef M. Pacyna)Assessment of Ecological and Health Effects of Soil-Borne Trace Elements and Metals (A.C. Chang and A.L. Page)Assessment of Metals in Drinking Water With Specific References to Lead, Copper, Arsenic, and Selenium (Anna M. Fan)Risk Assessment of Metals (J. Michael Davis and Robert W. Elias)Techniques Employed for the Assessment of Metals in Biological System (Richard M. Jacob)Concepts on Biological Markers and Biomonitoring for Metal Toxicity (Lars Gerhardsson and Staffan Skerfving)Bioresponses and Reactivities to Metal ToxicityAn Introduction to Bioresponses and Reactivities of Metals (Louis W. Chang)Determinants of Reactivity in Metal Toxicity (Evert Nieboer and Glenn G. Fletcher)Metals and Biological Membranes (Ernest C. Foulkes)Interactions Between Glutathione and Mercury in the Kidney, Liver, and Blood (Rudolfs K. Zalups and Lawrence H. Lash)The Role of General and Metal-Specific Cellular Responses in Protection and Repair of Metal-Induced Damage: Stress Proteins and Metallothioneins (Brenda M. Sanders, Peter L. Goering, and Kenneth Jenkins)Metal-Metal Interactions (Anada S. Prasad and Frances W. J. Beck)Carcinogenesis and Genotoxicity of MetalsPart A: Carcinogenicity and Genotoxicity of Specific MetalsAn Introduction to Metal Toxicity and Carcinogenicity of Metals (Max Costa)Carcinogenicity and Genotoxicity of Chromium (Catherine B. Klein)The Carcinogenicity of Arsenic (Zaolin Wang and Toby G. Rossman)Cadmium Carcinogenicity and Genotoxicity (Michael P. Waalkes and R. Rita Misra)Mechanisms of Nickel Genotoxicity and Carcinogenicity (Max Costa)Carcinogenicity and Genotoxicity of Lead, Beryllium, and Other Metals (Mitchell D. Cohen, Darlene H. Bowser, and Max Costa)Part B: Selected Concepts in Metal CarcinogenesisAn Introduction to Selected Concepts in Metal Carcinogenesis (Lionel A. Poirier)Metal Interactions in Chemical Carcinogenesis (Lionel A. Poirier and Neil A. Littlefield)Oxidative DNA Damage in Metal-Induced Carcinogenesis (Kazimierz S. Kasprzak)Metal-Induced Gene Expression and Neoplastic Transformation (Joseph R. Landolph, Michael Dews, Laurent Ozbun, and Douglas Parker Evans)Clinical Aspects of Metal ToxicityAn Introduction to Clinical Aspects of Metal Toxicity (Kazuo T. Suzuki and Tsuguyoshi Suzuki)Minamata Disease and Other Mercury Syndromes (Rikuzo Hamada and Mitsuhiro Osame)Itai-Itai Disease and Health Effects of Cadmium (Koji Nagawa and Teruhiko Kido)Genetic Disorders of Copper Metabolism (Hiroko Kodama)Alzheimer's Disease and Other Aluminum-Associated Health Conditions (D.R. McLachlan, P.E. Fraser, E. Jaikaran, and W.J. Lukiw)Current Status of Child