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This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly - chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.
Essentials of Apoptosis (2nd edition) Table of Contents Preface (2nd edition) Preface (1st edition) Contributors Part I. Molecules and Pathways of Apoptosis Chapter 1. Caspases: Activation, Regulation and FunctionStefan J. Riedl and Fiona L. Scott Chapter 2. Bcl-2 Family ProteinsWenxing Ding and Xiao-Ming Yin Chapter 3. The Mammalian IAPs: Multi-faceted Inhibitors of ApoptosisEric C. LaCasse, Herman H. Cheung, Allison M. Hunter, Stephanie Plenchette, Douglas J. Mahoney and Robert G. Korneluk Chapter 4. Structure Biology of Programmed Cell DeathYigong Shi Chapter 5. The Death Receptor PathwayMaria Eugenia Guicciardi and Gregory J. Gores Chapter 6. The Mitochondrial Pathway: Focus on Shape ChangesSilvia Campello and Luca Scorrano Chapter 7. The Endoplasm Reticulum PathwayMichael W. Harr and Clark W. Distelhorst Chapter 8. Reactive Oxygen Species in Cell Fate DecisionsHan-Ming Shen and Shazib Pervaiz Chapter 9. The Integration of Metabolism and Cell DeathJonathan L. Coloff, Yuxing Zhao and Jeffrey C. Rathmell Chapter 10. Transcriptional Regulation of ApoptosisCrissy Dudgeon, Wei Qiu, Quanhong Sun, Lin Zhang and Jian Yu Chapter 11. Clearance of Apoptotic cells --Mechanisms and ConsequencesCarylin J. Marek and Lars-Peter Erwig Chapter 12. Systems Biology Approach to the Study of ApoptosisHeinrich Huber, Eric Bullinger and Markus Rehm Part II: Apoptosis in Model Organisms Chapter 13. Programmed Cell Death in Plants: Apoptotic but not Quite Naohide Watanabe and Eric Lam Chapter 14. Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiaeDidac Carmona-Gutierrez and Frank Madeo Chapter 15. Programmed Cell Death in C. elegans. Monica Darland-Ransom, Yi-Chun Wu and Ding Xue Chapter 16. Cell Death in Drosophila. Dianne C. Purves, Jessica P. Monserrate and Carrie Baker Brachmann Part III. Apoptosis in Mammalian Physiology and Pathogenesis Chapter 17. Cell Death: Defining and Misshaping Mammalian Embryos Zahra Zakeri and Richard Lockshin Chapter 18. Matters of Life and Death in the Immune SystemChristopher Dillon and Douglas R. Green Chapter 19.Cell Death in the Hematopoietic SystemEmma C. Josefsson and Benjamin T. Kile Chapter 20 Cell Death in Acute Neuronal Injury R. Anne Stetler, Armando P. Signore and Jun Chen Chapter 21. Apoptosis in Neurodegenerative DiseasesQiuli Liang and Jianhua Zhang Chapter 22. Apoptosis in Cardiovascular PathogenesisHamid el Azzouzi; Meriem Bourajjaj; Paula A. da Costa Martins and Leon J. De Windt Chapter 23. Apoptosis in Lung Injury and Disease Stefan W. Ryter, Hong Pyo Kim, and Augustine M. K. Choi Chapter 24. Apoptosis in the Liver Injury and Liver DiseasesYosuke Osawa, Ekihiro Seki, and David A Brenner Chapter 25. Apoptosis in Kidney InjuryNavjotsingh Pabla, Qingqing Wei, Zheng Dong Chapter 26. Apoptosis in Cancer Biology and Cancer TherapeuticsSimone Fulda Part IV. Alternative cell death mechanisms and pathways Chapter 27. Necrosis, Molecular Mechanisms and its Role in PhysiologyLinde Duprez, Nele Vanlangenakker, Nele Festjens, Franky Van Herreweghe, Tom Vanden Berghe, Peter Vandenabeele Chapter 28. Caspase-independent Mitotic DeathKatsumi Kitagawa Chapter 29.Lysosomal Proteases in Cell Death Nathalie Andrieu-Abadie Chapter 30. Autophagy and Cell DeathWentao Gao, Jeong-Han Kang, Yong Liao, Min Li and Xiao-Ming Yin Part V. Approaches to the study of apoptosis Chapter 31. Analysis of Apoptosis: Basic Principles and ProtocolsMan Jiang, Craig Brooks, Guie Dong, Xiaoning Li, Hong-Min Ni, Xiao-Ming Yin, Zheng Dong Index
From the reviews of the second edition: "This book comprehensively reviews knowledge of the main mechanism of cell death, apoptosis, both from the molecular viewpoint and in relation to the roles of this process in mammalian physiology and pathology. ! chapters are well written and scholarly in content and present the reader with a thorough and up-to-date insight into these fields. This book is highly recommended for scientists working in many areas of cell or developmental biology, as well as those involved in more clinical fields, such as neurobiology or molecular oncology." (Mike Clemens, Microbiology Today, November, 2009) "The book 'Essentials of Apoptosis' is a collection of 31 review articles, covering a wide variety of approaches in studying cell death. ! It enables the reader to get acquainted with many aspects of apoptosis, and impressive amounts of references cited in each of the article allows for further studies on the subject. I recommend this book to anyone seriously interested in research on programmed dell death." (Piotr P. Stepien, Acta Biochimica Polonica, December, 2010) "Prof. Yin and Prof. Dong ! were able to cover both conceptual and practical aspects as well as both basic and applied research aspects, thus leading to translation research aspects in biomedicine, which is a crucial hot topic in modern biomedical clinic. ! the potential readership is made up of the entire scientific comunity ! and cellular biologists, developmental biologists, protein scientists." (CarloAlberto Redi, European Journal of Histochemistry, Vol. 54 (e11), 2010)