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Pharmacogenomics: Methods and Applications

Handbook / Manual

Series: Methods in Molecular Biology Volume: 311

By: Federico Innocenti

Humana Press

Hardback | Dec 2005 | #163678 | ISBN: 1588294404
Availability: Usually dispatched within 1 week Details
NHBS Price: £119.99 $162/€137 approx

About this book

Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.


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