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Leading experts in nanobiotechnology comprehensively review the most recent advances in instrumentation and methodology, as well as their applications in genomics and proteomics. The authors provide a wide variety of techniques and methods for dealing with protein functions and structures at the nanoscale level, including nanostructured systems, nanomaterials, carbon nanotubes and nanowires, optical nanosensors, and nanoelectrodes. Among the highlights are techniques for the in vivo tracking of biochemical processes using fluorescent molecular probes and nanosensors, and the exploration of biochemical processes and submicroscopic structures of living cells at unprecedented resolutions using near-field optics. Also discussed is the development of nanocarrier methodology for the targeted delivery of drugs whose shells are conjugated with antibodies for targeting specific antigens.
1 Protein Nanotechnology: The New Frontier in Biosciences Tuan Vo-Dinh 2 Kinetics and Mechanisms of Protein Crystallization at the Molecular Level Peter G. Vekilov 3 Nanostructured Systems for Biological Materials Esther H. Lan, Bruce Dunn, and Jeffrey I. Zink 4 Nanomaterials of Drug Delivery Systems for Tissue Regeneration Yasuhiko Tabata 5 Nanotechnology with S-Layer Proteins Bernard Schuster, D. Pum, U. B. Sleytr, and E. Gyorvary 6 Folding of Beta-Structured Fibrous Proteins and Self-Assembling Peptides Anna Mitraki and Mark J. van Raaij 7 Application of NMR Methods to Identify Detection Reagents for Use in the Development of Robust Nanosensors Monique Cosman, V. V. Krishnan, and Rod Balhorn 8 Studying 3-D Sub-Domains of Proteins at the Nanometer Scale Using Fluorescence Spectroscopy Pierre M. Viallet and Tuan Vo-Dinh 9 Carbon Nanotubes and Nanowires for Biological Sensing Jun Li, Hou Tee Ng, and Hua Chen 10 Carbon Nanotube Systems to Communicate with Enzymes J. Justin Gooding and Joe G. Shapter 11 Molecularly Imprinted Polymers for Biomolecular Recognition Alexandra Molinelli, Markus Janotta,and Boris Mizaikoff 12 Plasmonics-Based Nanotructures for Surface-Enhanced Raman Scattering Bioanalysis Tuan Vo-Dinh, Fei Yan, and David L. Stokes 13. Bacterial Virus phi29 DNA-Packaging Motor and Its Potential Applications in Gene Therapy and Nanotechnology Peixuan Guo 14 Construction of Ordered Protein Arrays Jarrod Clark, Taras Shevchuk, Piotr M. Swiderski, Rajesh Dabur, Laura E. Crocitto, Yaroslav I. Buryanov, and Steven S. Smith 15 Nano-Assemblies of DNA Protein Systems: Bioengineering and Characterization of DNA-Protein Assemblies Floating on Supported Membranes W. Boireau, A. C. Duncan, and Denis Pompon 16 Nanosystems for Biosensing: Multianalyte Immunoassay on a Protein Chip Eiichi Tamiya, Zheng-liang Zhi, Yasutaka Morita, and Quamrul Hasan 17. Optical Nanosensors for Detecting Proteins and Biomarkers in Individual Living Cells Tuan Vo-Dinh 18. Nanoelectrodes Integrated in AFM Cantilevers for In Situ Enzyme Activity Imaging Angelika Kueng, Christine Kranz, Alois Lugstein, Emmerich Bertagnolli, and Boris Mizaikoff 19. Protein Amyloidose Folding: Mechanisms, Detection, and Pathological Implications Nigil Satish, Ajit Sadana, and Tuan Vo-Dinh 20. Near-Field Scanning Optical Microscopy for Bioanalysis at the Nanometer Resolution Musundi B. Wabuyele, Mustafa Culha, Guy D. Griffin, Pierre M. Viallet, and Tuan Vo-Dinh